Product Overview
(-)-Praeruptorin A | TN4819 | TargetMol Chemicals
CAS: 14017-71-1
Smiles: C\C=C(\C)C(=O)O[C@@H]1[C@H](OC(C)=O)c2c(OC1(C)C)ccc1ccc(=O)oc21
Formula: C21H22O7
Pathway: Immunology/Inflammation|||Membrane transporter/Ion channel|||Metabolism|||Neuroscience
Target: ATPase|||IL Receptor|||Calcium Channel|||P-gp
Receptor: N/A
Bioactivity: (-)-Praeruptorin A has anti-inflammatory, anti-contractile and anti-hyperplasia activities, it exerts distinct relaxant effects on isolated rat aorta rings dependent on endothelium and nitric oxide synthesis;it also can significantly suppress airway inflammation and airway remodeling induced by ovalbumin challenge, and is a potential candidate for the treatment of asthma. (-)-Praeruptorin A resensitizes Pgp-mediated MDR (Pgp-MDR) cancer cells to cancer drugs.
Molecular Weight: 386, 39
