Product Overview
PTC-028 | T16680 | TargetMol Chemicals
CAS: 1782970-28-8
Smiles: Cc1nc2cc(F)c(F)cc2n1-c1cncc(Nc2ccc(cc2)C(F)(F)F)n1
Formula: C19H12F5N5
Pathway: Apoptosis|||Cell Cycle/Checkpoint|||DNA Damage/DNA Repair
Target: Apoptosis|||BMI-1
Receptor: N/A
Bioactivity: PTC-028 selectively suppresses cancer cells whereas normal cells remain unaffected. PTC-028 is an orally bioavailable inhibitor of stem cell factor BMI-1 in ovarian cancer. The depletion of BMI-1 by PTC-028 causes caspase-mediated apoptosis.
Molecular Weight: 405, 332
