Product Overview
R-1663 | T28491 | TargetMol Chemicals
CAS: 865451-66-7
Smiles: O=C(N1[C@@H](C(NC2=CC=C(N3C(COCC3)=O)C=C2)=O)C[C@@H](O)C1)NC4=CC=C(Cl)C=C4
Formula: C22H23ClN4O5
Pathway: N/A
Target: N/A
Receptor: N/A
Bioactivity: R-1663 is a factor Xa inhibitor. R-1663 prolonged clotting times, inhibited thrombin generation (peak height and endogenous thrombin potential [ETP]) and anti-factor Xa activity in a concentration-dependent manner without increasing bleeding time. Pharmacodynamic parameters were strongly correlated to R-1663 plasma concentrations. The inhibition was more pronounced on peak height (IC₅₀ = 194 ng/ml) than on ETP (2790 ng/ml).
Molecular Weight: 458, 9
