Product Overview
(Rac)-SAR131675 | T3691 | TargetMol Chemicals
CAS: 1092539-44-0
Smiles: CCn1c(N)c(C(=O)NC)c(=O)c2ccc(nc12)C#CC(C)(O)COC
Formula: C18H22N4O4
Pathway: Angiogenesis|||Tyrosine Kinase/Adaptors
Target: VEGFR
Receptor: N/A
Bioactivity: SAR131675 is an effective and specific VEGFR-3 inhibitor. It inhibited VEGFR-3 tyrosine kinase activity (IC50: 20 nmol/L) and VEGFR-3 autophosphorylation (IC50: 45 nmol/L) in HEK cells, respectively. SAR131675 is highly specific for VEGFR-3 versus 107 receptors, enzymes, ion channels, and 65 kinases. SAR131675 is a highly specific VEGFR-3-TK inhibitor with significant antitumoral and antimetastatic activities in vivo through inhibition of lymphangiogenesis and TAM invasion.
Molecular Weight: 358, 398
