Product Overview
Regorafenib monohydrate | T1792L | TargetMol Chemicals
CAS: 1019206-88-2
Smiles: O.CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)c(F)c2)ccn1
Formula: C21H17ClF4N4O4
Pathway: Angiogenesis|||Apoptosis|||Autophagy|||MAPK|||Tyrosine Kinase/Adaptors
Target: Raf|||VEGFR|||c-RET|||PDGFR|||c-Kit|||Autophagy
Receptor: N/A
Bioactivity: Regorafenib Monohydrate is a novel oral multikinase inhibitor with IC50 values of 13, 4.2, 46, 22, 7, 1.5, 2.5, 28, 19 nM for VEGFR1, murine VEGFR2, murine VEGFR3, PDGFR-β, KIT, RET, RAF-1, B-RAF and B-RAF(V600E) respectively.
Molecular Weight: 500, 83
