Product Overview
Rheb inhibitor NR1 | T16741 | TargetMol Chemicals
CAS: 2216763-38-9
Smiles: CN(C)C(=O)c1ccc(Cn2c(cc3c(Br)cc(Sc4ccc(Cl)c(Cl)c4)cc23)C(O)=O)cc1
Formula: C25H19BrCl2N2O3S
Pathway: Others
Target: Others
Receptor: N/A
Bioactivity: Rheb inhibitor NR1 inhibits the phosphorylation of T389pS6K1 and increases the phosphorylation of S473pAKT in a dose-dependent manner. Rheb inhibitor NR1 is a Rheb inhibitor (IC50: 2.1 μM in the Rheb-IVK assay). NR1 also is a selective mTORC1 inhibitor.
Molecular Weight: 578, 3
