Product Overview
RO 46-8443 | T3474 | TargetMol Chemicals
CAS: 175556-12-4
Smiles: COc1ccc(cc1)-c1nc(NS(=O)(=O)c2ccc(cc2)C(C)(C)C)c(Oc2ccccc2OC)c(OC[C@H](O)CO)n1
Formula: C31H35N3O8S
Pathway: GPCR/G Protein
Target: Endothelin Receptor
Receptor: N/A
Bioactivity: RO 46-8443 is the first non-peptide endothelin ETB receptor selective antagonist. RO 46-8443 displays up to 2000-fold selectivity for ETB receptors both in terms of binding inhibitory potency and functional inhibition.
Molecular Weight: 609, 69
