Product Overview
Scutebarbatine A | TN2191 | TargetMol Chemicals
CAS: 176520-13-1
Smiles: [H][C@]12CCC=C(C)[C@]1(C)[C@@H](OC(=O)c1cccnc1)[C@H](OC(=O)c1cccnc1)[C@](C)(O)[C@]2(C)\C=C\C1=CC(=O)OC1
Formula: C32H34N2O7
Pathway: Apoptosis|||Proteases/Proteasome
Target: BCL|||Caspase
Receptor: N/A
Bioactivity: Scutebarbatine A shows significant antitumor effects on A549 cells in vivo and in vitro via mitochondria-mediated apoptosis by up-regulating expressions of caspase-3 and 9, and down-regulating Bcl-2. Scutebarbatine A and barbatine A show a significant ability to protect cells against H2O2 with ED50 values of 5.0 and 16.8 μM, respectively.
Molecular Weight: 558, 631
