Product Overview
SD-36 | T18680 | TargetMol Chemicals
CAS: 2429877-44-9
Smiles:
Formula: N/A
Pathway: Others
Target: Others
Receptor: N/A
Bioactivity: SD-36 is a potent and efficacious PROTAC STAT3 degrader (Kd=~50 nM), and demonstrates high selectivity over other STAT members. SD-36 also effectively degrades mutated STAT3 proteins in cells and suppresses the transcriptional activity of STAT3 (IC50=10 nM). SD-36 exerts robust anti-tumor activity, and achieves complete and long-lasting tumor regression in mouse tumor models. SD-36 is composed of the STAT3 inhibitor SI-109, a linker, and an analog of CRBN ligand Lenalidomide for E3 ubiquitin ligase[1].
Molecular Weight: N/A
