Product Overview
Semagacestat | T6125 | TargetMol Chemicals
CAS: 425386-60-3
Smiles: C[C@@H](C(=O)N[C@H]1c2ccccc2CCN(C1=O)C)NC(=O)[C@H](C(C)C)O
Formula: C19H27N3O4
Pathway: Neuroscience|||Proteases/Proteasome|||Stem Cells
Target: Beta Amyloid|||Gamma-secretase
Receptor: N/A
Bioactivity: Semagacestat (LY450139) is a γ-secretase blocker for Aβ42/Aβ40/Aβ38 (IC50: 10.9/12.1/12.0 nM) and also inhibits Notch signaling (IC50: 14.1 nM).
Molecular Weight: 361, 44