Product Overview
Senicapoc | T3528 | TargetMol Chemicals
CAS: 289656-45-7
Smiles: NC(=O)C(c1ccccc1)(c1ccc(F)cc1)c1ccc(F)cc1
Formula: C20H15F2NO
Pathway: Membrane transporter/Ion channel
Target: Potassium Channel
Receptor: N/A
Bioactivity: Senicapoc is a potent inhibitor of the Gardos channel and ameliorates RBC dehydration in the SAD mouse. Senicapoc blocked Ca2+-induced rubidium flux from human RBCs with an IC50 value of 11 ± 2 nM (CLT IC50 = 100 ± 12 nM) and inhibited RBC dehydration with an IC50 of 30 ± 20 nM. Senicapoc is in treatment of Sickle Cell Disease and Sickle Cell Anemia
Molecular Weight: 323, 343