Product Overview
SGC2085 HCl | T4013 | TargetMol Chemicals
CAS: 1821908-49-9
Smiles: Cl.C[C@H](N)C(=O)NCc1ccc(Oc2cc(C)cc(C)c2)c(C)c1
Formula: C19H25ClN2O2
Pathway: Chromatin/Epigenetic
Target: Histone Methyltransferase
Receptor: N/A
Bioactivity: SGC2085 is a potent and selective coactivator associated arginine methyltransferase 1 (CARM1) Inhibitor with an IC50 of 50 nM and more than undred-fold selectivity over other PRMTs. CARM1 is an important positive modulator of Wnt/β-catenin transcription and neoplastic transformation in colorectal cancer as well as a critical factor in estrogen-stimulated breast cancer growth, and its depletion results in decreased proliferation of myeloid leukemia cells in vivo.
Molecular Weight: 348, 87
