Shizukaol B | TN5011

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Shizukaol B | TN5011 | TargetMol Chemicals

CAS: 142279-40-1

Smiles: COC(=O)C(\C)=C1\[C@H]2C3=C(C[C@H]4[C@@]5(C)[C@@H]6C[C@@H]6[C@@]6(O)COC(=O)\C(C)=C\COC(=O)CCC(=O)OCC7=C(C[C@H]56)[C@@]24OC7=O)[C@H]2C[C@H]2[C@]3(C)[C@@H](O)C1=O

Formula: C40H44O13

Pathway: Apoptosis|||Cell Cycle/Checkpoint|||DNA Damage/DNA Repair|||GPCR/G Protein|||Immunology/Inflammation|||MAPK|||Microbiology/Virology|||Neuroscience|||NF-Κb|||Proteases/Proteasome

Target: ERK|||IL Receptor|||p38 MAPK|||TNF|||NOS|||NF-κB|||COX|||HIV Protease|||DNA/RNA Synthesis|||Prostaglandin Receptor|||JNK

Receptor: N/A

Bioactivity: Shizukaol B exerts anti-inflammatory effects in LPS-activated microglia partly by modulating JNK-AP-1 signaling pathway; it also shows significant anti-neuroinflammatory effects by inhibiting nitric-oxide (NO) production in lipopolysaccharide (LPS)-stimulated murine BV-2 microglial cells with relatively low cytotoxicity. Shizukaol B exhibits anti-HIV-1 replication activities in both wild-type HIV-1 and two NNRTIs-resistant strains, it also has significant cytotoxicities against C8166 cells. Shizukaol B prevents monocyte adhesion to HUVEC through the inhibition of cell adhesion molecules expression stimulated by TNF-alpha.

Molecular Weight: 732, 77


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