Product Overview
SKI-178 | T9014 | TargetMol Chemicals
CAS: 1259484-97-3
Smiles: COc1ccc(cc1)-c1cc([nH]n1)C(=O)N\N=C(/C)c1ccc(OC)c(OC)c1
Formula: C21H22N4O4
Pathway: Apoptosis|||GPCR/G Protein
Target: Apoptosis|||S1P Receptor
Receptor: N/A
Bioactivity: SKI-178 is a sphingosine kinase 1 (SphK1) inhibitor with IC50 of 0.1-1.8 μM. It induces prolonged mitosis followed by apoptotic cell death through the intrinsic apoptotic cascade. The sustained activation of CDK1 during prolonged mitosis, mediated by SKI-178 leads to the simultaneous phosphorylation of the prosurvival Bcl-2 family members, Bcl-2 and Bcl-xl, as well as the phosphorylation and subsequent degradation of Mcl-1.
Molecular Weight: 394, 431
