Product Overview
SNIPER(ER)-87 | T18697 | TargetMol Chemicals
CAS: 2222354-91-6
Smiles: CC\C(=C(\c1ccc(O)cc1)c1ccc(OCCN(C)C(=O)COCCOCCOCCOc2cccc(c2)C(=O)c2csc(n2)[C@@H]2CCCN2C(=O)[C@@H](NC(=O)[C@H](C)NC)C2CCCCC2)cc1)c1ccccc1
Formula: C59H73N5O10S
Pathway: Others
Target: Others
Receptor: N/A
Bioactivity: SNIPER(ER)-87 consists of an inhibitor of apoptosis protein (IAP) ligand LCL161 derivative that is conjugated to the estrogen receptor α (ERα) ligand 4-hydroxytamoxifen by a PEG linker, and efficiently degrades the ERα protein (IC50=0.097 μM). SNIPER(ER)-87 preferentially recruits XIAP to ERα in the cells, and XIAP is the primary E3 ubiquitin ligase responsible for the SNIPER(ER)-87-induced ERα degradation[1][2].
Molecular Weight: 1044, 32
