Product Overview
Sulindac | T0459 | TargetMol Chemicals
CAS: 38194-50-2
Smiles: CC1=C(CC(O)=O)c2cc(F)ccc2\C1=C/c1ccc(cc1)S(C)=O
Formula: C20H17FO3S
Pathway: Autophagy|||Immunology/Inflammation|||Neuroscience
Target: COX|||Autophagy
Receptor: N/A
Bioactivity: Sulindac is a sulfinylindene derivative prodrug with potential antineoplastic activity. Converted in vivo to an active metabolite, sulindac, a nonsteroidal anti-inflammatory drug (NSAID), blocks cyclic guanosine monophosphate-phosphodiesterase (cGMP-PDE), an enzyme that inhibits the normal apoptosis signal pathway; this inhibition permits the apoptotic signal pathway to proceed unopposed, resulting in apoptotic cell death.
Molecular Weight: 356, 41
