Product Overview
Syk Inhibitor II (hydrochloride) | T4391 | TargetMol Chemicals
CAS: 227449-73-2
Smiles: Cl.Cl.NCCNc1ncc(C(N)=O)c(Nc2cccc(c2)C(F)(F)F)n1
Formula: C14H17Cl2F3N6O
Pathway: Angiogenesis|||Chromatin/Epigenetic|||Cytoskeletal Signaling|||Others|||Tyrosine Kinase/Adaptors
Target: Others|||Tyrosine Kinases|||Syk|||PKC|||BTK
Receptor: N/A
Bioactivity: Spleen tyrosine kinase (Syk) is a non-receptor tyrosine kinase that, upon phosphorylation, binds to immunoreceptor tyrosine-based activation motifs of FcRγ chains and mediates downstream signaling related to platelet function and inflammation. Syk inhibitor II is a cell-permeable, pyrimidine-carboxamide compound that selectively and reversibly blocks Syk (IC50 = 41 nM) in an ATP-competitive manner. It is much less potent against PKCε, PKCβII, ZAP-70, Btk, and Itk (IC50s = 5.1, 11, 11.2, 15.5, and 22.6 μM, respectively).
Molecular Weight: 413, 23
