Syk Inhibitor II hydrochloride | T9543

(No reviews yet) Write a Review
€308.00 - €4,291.00
Adding to cart… The item has been added

Product Overview

Syk Inhibitor II hydrochloride | T9543 | TargetMol Chemicals

CAS: 2490508-82-0


Formula: N/A

Pathway: Others

Target: Others

Receptor: N/A

Bioactivity: The impact of spleen tyrosine kinase (Syk) signaling might be prominent in lupus because (i) Syk is a shared downstream signaling molecule among circulating immune complex, LPS, and (1→3)-β-D-glucan (BG), and (ii) all of these factors are detectable in the serum of Fc gamma receptor IIb-deficient (FcgRIIb-/-) mice with sepsis. Syk inhibition downregulated several inflammatory pathways in FcgRIIb-/- macrophages activated with BG + LPS suggesting the potential anti-inflammatory impact of Syk inhibitors in lupus. Indeed, administration of a Syk inhibitor prior to cecal ligation and puncture (CLP) sepsis in FcgRIIb-/- mice reduced baseline lupus-induced proinflammatory cytokines and attenuated sepsis severity as evaluated by mortality, organ injury, serum LPS, and post-sepsis serum cytokines.

Molecular Weight: N/A


(No reviews yet) Write a Review