Product Overview
Taspine | TN5100 | TargetMol Chemicals
CAS: 602-07-3
Smiles: COc1ccc2c3c1oc(=O)c1c(CCN(C)C)cc(OC)c(oc2=O)c31
Formula: C20H19NO6
Pathway: Angiogenesis|||Apoptosis|||Cytoskeletal Signaling|||JAK/STAT signaling|||MAPK|||PI3K/Akt/mTOR signaling|||Tyrosine Kinase/Adaptors
Target: ERK|||EGFR|||BCL|||VEGFR|||MAPK|||Akt
Receptor: N/A
Bioactivity: Taspine shows antitumor activity by modulating the EGFR signaling pathway of Erk1/2 and Akt in vitro and in vivo, it can inhibit growth and induce apoptosis of HUVEC in a dose-dependent manner, it has shown meaningful angiogenesis activity. Taspine exhibits a dose-related cicatrizant effect and an ED50 of 0.375 mg/kg.
Molecular Weight: 369, 37