Product Overview
TCS 21311 | T17019 | TargetMol Chemicals
CAS: 1260181-14-3
Smiles: CC(C)(O)C(=O)N1CCN(CC1)c1ccc(c(c1)C1=C(C(=O)NC1=O)c1c[nH]c2ccccc12)C(F)(F)F
Formula: C27H25F3N4O4
Pathway: Angiogenesis|||Chromatin/Epigenetic|||Cytoskeletal Signaling|||JAK/STAT signaling|||PI3K/Akt/mTOR signaling|||Stem Cells
Target: GSK-3|||JAK|||PKC
Receptor: N/A
Bioactivity: TCS 21311 is an effective and highly selective inhibitor of JAK3 (IC50: 8 nM). TCS 21311 inhibits PKCα, PKCθ, and GSK3β (IC50s: 13, 68, and 3 nM, respectively). It displays >100-fold selectivity over JAK1, JAK2, and TYK2.
Molecular Weight: 526, 516
