Product Overview
TG6-129 | T28958 | TargetMol Chemicals
CAS: 1164464-14-5
Smiles: CCc1nnc(NS(=O)(=O)c2ccc(NC(=S)NC(=O)\C=C\c3ccc(F)cc3)cc2)s1
Formula: C20H18FN5O3S3
Pathway: GPCR/G Protein|||Immunology/Inflammation
Target: Prostaglandin Receptor
Receptor: N/A
Bioactivity: TG6-129 is an antagonist of the EP2 receptor. TG6-129 suppresses PGE2-induced elevation of cAMP in cells expressing EP2 with an IC50 value of 1.6 µM. TG6-129 reduces the expression of COX-2, IL-1β, IL-6, IL-12, IL-23 and TNF-α induced by the EP2-selective agonist butaprost in P388D1 macrophages.
Molecular Weight: 491, 57
