Product Overview
Topovale | T9088 | TargetMol Chemicals
CAS: 500214-53-9
Smiles: COc1cc2c3cnc4cc5OCOc5cc4c3n(CCN(C)C)c(=O)c2cc1OC
Formula: C23H23N3O5
Pathway: DNA Damage/DNA Repair
Target: Topoisomerase
Receptor: N/A
Bioactivity: Topovale is a potent inhibitor of topoisomerase I. Topovale inhibits hypoxia-mediated accumulation of hypoxia-inducible factor-1alpha. Topovale exhibited low nM cytotoxicity against a panel of cancer cells. Topovale cytotoxicity as well as Topovale-induced apoptosis was reduced > 100-fold in CPT-resistant topoisomerase I (TOP1)-deficient P388/CPT45 cells as compared with P388 cells.
Molecular Weight: 421, 453