Product Overview
TP-064 | T28996 | TargetMol Chemicals
CAS: 2080306-20-1
Smiles: CNCCN1CCC(CC1)c1cc(CN(C)C(=O)c2cccc(Oc3ccccc3)c2)ccn1
Formula: C28H34N4O2
Pathway: Chromatin/Epigenetic
Target: Histone Methyltransferase
Receptor: N/A
Bioactivity: TP-064 is a potent and selective PRMT4 inhibitor. TP-064 includes inhibition of PRMT4 with IC50 < 10nM for methylation of H3 (1-25) and greater than 100-fold selectivity over other histone methyltransferases and non-epigenetic targets. TP-064 inhibits the methylation of MED12 with IC50 = 43 nM in cell.
Molecular Weight: 458, 606
