Product Overview
Trametinib | T2125 | TargetMol Chemicals
CAS: 871700-17-3
Smiles: CC(=O)Nc1cccc(c1)-n1c2c(C)c(=O)n(C)c(Nc3ccc(I)cc3F)c2c(=O)n(C2CC2)c1=O
Formula: C26H23FIN5O4
Pathway: Apoptosis|||Autophagy|||MAPK
Target: Apoptosis|||MEK|||Autophagy
Receptor: N/A
Bioactivity: Trametinib is an ATP-noncompetitive inhibitor of MEK 1/2 (IC50s: 0.7/0.9 nM). It shows low inhibition for more than 180 kinases, including B-Raf, c-Raf, and MEK5.
Molecular Weight: 615, 404
