Product Overview
TRV-120027 TFA | TP2158 | TargetMol Chemicals
CAS: TP2158
Smiles:
Formula: C45H68F3N13O12
Pathway: Endocrinology/Hormones
Target: RAAS
Receptor: N/A
Bioactivity: TRV-120027 TFA is an angiotensin II–mediated vasoconstriction inhibitor and increases cardiomyocyte contractility. TRV-120027 TFA is a β-arrestin-1-biased AT1R agonist engaging ß-arrestins while blocking G-protein signaling[1]. TRV-120027 TFA induces acute catecholamine secretion through cation channel subfamily C3 (TRPC3) coupling and promotes the formation of a macromolecular complex composed of AT1R–β-arrestin-1–TRPC3–PLCγ at the plasma membrane.
Molecular Weight: 1040, 1
