Product Overview
Tuxobertinib | T9072 | TargetMol Chemicals
CAS: 2414572-47-5
Smiles: C=CC(=O)NC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC(=C(C=C3)OCC4=CC=CC=N4)Cl)OCCN5CCOCC5
Formula: C29H29ClN6O4
Pathway: Angiogenesis|||Apoptosis|||JAK/STAT signaling|||NF-Κb|||Tyrosine Kinase/Adaptors
Target: EGFR|||HER|||BTK|||RIP kinase
Receptor: N/A
Bioactivity: BDTX-189 is a potent and selective inhibitor of allosteric EGFR and HER2 oncogenic mutations(KDs of 0.2, 0.76, 13 and 1.2 nM for EGFR, HER2, BLK and RIPK2, reapectively). BDTX-189 exhibits anticancer activity.
Molecular Weight: 561, 03