Product Overview
UNC0646 | TQ0232 | TargetMol Chemicals
CAS: 1320288-17-2
Smiles: COc1cc2c(NC3CCN(CC3)C3CCCCC3)nc(nc2cc1OCCCN1CCCCC1)N1CCCN(CC1)C(C)C
Formula: C36H59N7O2
Pathway: Chromatin/Epigenetic
Target: Histone Methyltransferase
Receptor: N/A
Bioactivity: UNC 0646 is a potent and selective inhibitor of the homologous protein lysine methyltransferases, G9a and GLP (IC50s: 6 nM/15 nM for G9a/GLP). UNC0646 potently blocks G9a/GLP methyltransferase activity in cells (IC50: 10 nM in MCF7 cells); exhibits low cellular toxicity (EC50: 4.7 μM in MCF7 cells).
Molecular Weight: 621, 915