Product Overview
VHL Ligand-Linker Conjugates 17 | T18873 | TargetMol Chemicals
CAS: T18873
Smiles: O=C(C[C@@H](C1=CC=CC=C1)NC([C@H]2N(C([C@H](C(C)C)C3=CC(C)=NO3)=O)C[C@H](O)C2)=O)N(CC4)CCC4C#CC5=CC=C(C(O)=O)C=C5
Formula: C37H42N4O7
Pathway: Others
Target: Others
Receptor: N/A
Bioactivity: VHL Ligand-Linker Conjugates 17 incorporates a VHL ligand for the E3 ubiquitin ligase, and a PROTAC linker. VHL Ligand-Linker Conjugates 17 can be used in the synthesis of a series of PROTACs, such as ARD-266. ARD-266 is a highly potent androgen receptor (AR) PROTAC degrader[1].
Molecular Weight: 654, 75
