Product Overview
Wortmannin | T6283 | TargetMol Chemicals
CAS: 19545-26-7
Smiles: [H][C@@]12CCC(=O)[C@@]1(C)C[C@@H](OC(C)=O)C1=C2C(=O)c2occ3c2[C@]1(C)[C@@H](COC)OC3=O
Formula: C23H24O8
Pathway: Autophagy|||Cell Cycle/Checkpoint|||DNA Damage/DNA Repair|||Metabolism|||Microbiology/Virology|||PI3K/Akt/mTOR signaling
Target: ATM/ATR|||DNA-PK|||Serine/threonin kinase|||PLK|||PI3K|||Antibiotic|||Autophagy
Receptor: N/A
Bioactivity: Wortmannin is the first described PI3K inhibitor with IC50 of 3 nM, with little selectivity within the PI3K family. Also blocks autophagosome formation and potently inhibits DNA-PK/ATM with IC50 of 16 nM and 150 nM.
Molecular Weight: 428, 437