Product Overview
WYE-354 | T6731 | TargetMol Chemicals
CAS: 1062169-56-5
Smiles: COC(=O)Nc1ccc(cc1)-c1nc(N2CCOCC2)c2cnn(C3CCN(CC3)C(=O)OC)c2n1
Formula: C24H29N7O5
Pathway: Apoptosis|||Autophagy|||PI3K/Akt/mTOR signaling
Target: Apoptosis|||PI3K|||mTOR|||Autophagy
Receptor: N/A
Bioactivity: WYE-354(IC50=5 nM) is an effective, selective and ATP-competitive mTOR inhibitor. It blocks mTORC2/P-AKT(S473) and mTORC1/P-S6K(T389), not P-AKT(T308). The selectivity for mTOR is higher than PI3Kα (>100-fold) and PI3Kγ (>500-fold).
Molecular Weight: 495, 54
