Product Overview
WYE-687 | T6732 | TargetMol Chemicals
CAS: 1062161-90-3
Smiles: COC(=O)Nc1ccc(cc1)-c1nc(N2CCOCC2)c2cnn(C3CCN(Cc4cccnc4)CC3)c2n1
Formula: C28H32N8O3
Pathway: Angiogenesis|||MAPK|||PI3K/Akt/mTOR signaling|||Tyrosine Kinase/Adaptors
Target: p38 MAPK|||PI3K|||Src|||mTOR
Receptor: N/A
Bioactivity: WYE-687 is an ATP-competitive and selective inhibitor of mTOR with IC50 of 7 nM; blocks mTORC1/pS6K(T389) and mTORC2/P-AKT(S473) but no effect observed on P-AKT(T308). Selectivity for mTOR is greater than PI3Kα (>100-fold) and PI3Kγ (>500-fold).
Molecular Weight: 528, 617
