Product Overview
X-376 | T3550 | TargetMol Chemicals
CAS: 1365267-27-1
Smiles: C[C@@H](Oc1cc(nnc1N)C(=O)Nc1ccc(cc1)C(=O)N1CCN(C)CC1)c1c(Cl)ccc(F)c1Cl
Formula: C25H25Cl2FN6O3
Pathway: Angiogenesis|||Tyrosine Kinase/Adaptors
Target: c-Met/HGFR|||ALK
Receptor: N/A
Bioactivity: Ensartinib (X-396) is an orally available small molecule inhibitor of the receptor tyrosine kinase anaplastic lymphoma kinase (ALK) with potential antineoplastic activity. Upon oral administration, X-396 binds to and inhibits ALK kinase, ALK fusion proteins, and ALK point mutation variants. Inhibition of ALK leads to the disruption of ALK-mediated signaling and eventually inhibits tumor cell growth in ALK-expressing tumor cells. ALK belongs to the insulin receptor superfamily and plays an important role in nervous system development.
Molecular Weight: 547, 41
