Product Overview
AMG-458 | T6378 | TargetMol Chemicals
CAS: 913376-83-7
Smiles: COc1ccc2c(Oc3ccc(NC(=O)c4c(C)n(CC(C)(C)O)n(-c5ccccc5)c4=O)nc3)ccnc2c1
Formula: C30H29N5O5
Pathway: Tyrosine Kinase/Adaptors
Target: c-Met/HGFR
Receptor: N/A
Bioactivity: AMG 458 is a potent c-Met inhibitor with Ki of 1.2 nM, ~350-fold selectivity for c-Met than VEGFR2 in cells.
Molecular Weight: 539, 592
