Product Overview
AMG 517 | T6379 | TargetMol Chemicals
CAS: 659730-32-2
Smiles: CC(=O)Nc1nc2c(Oc3cc(ncn3)-c3ccc(cc3)C(F)(F)F)cccc2s1
Formula: C20H13F3N4O2S
Pathway: Membrane transporter/Ion channel
Target: TRP/TRPV Channel
Receptor: N/A
Bioactivity: AMG 517 is an effective and specific TRPV1 antagonist, antagonizes proton (IC50: 0.76 nM), capsaicin (IC50: 0.62 nM), and heat activation (IC50: 1.3 nM) of TRPV1.
Molecular Weight: 430, 41
