Product Overview
CLOZAPINE N-OXIDE | T4494 | TargetMol Chemicals
CAS: 34233-69-7
Smiles: C[N+]1([O-])CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2ccccc12
Formula: C18H19ClN4O
Pathway: GPCR/G Protein|||Metabolism|||Neuroscience
Target: Dopamine Receptor|||5-HT Receptor|||AChR|||Drug Metabolite
Receptor: N/A
Bioactivity: Clozapine N-oxide is a major metabolite of clozapine that can be detected in the earliest excretion time interval after clozapine administration [1]. It is produced by the action of cytochrome P450 (CYP) isoforms CYP1A2 and CYP3A4, whose activities, in turn, can be affected by drugs and disease [2]. Clozapine N-oxide is normally biologically inactive. However, it can be used in designer receptor exclusively activated by designer drugs, also known as DREADDs, technology to modulate synthetic receptors in vivo [3].
Molecular Weight: 342, 83
