Product Overview
Huwentoxin-IV | TP2016 | TargetMol Chemicals
CAS: 526224-73-7
Smiles:
Formula: C174H278N52O51S6
Pathway: N/A
Target: N/A
Receptor: N/A
Bioactivity: Selective NaV1.7 channel blocker. Preferentially inhibits neuronal NaV1.7, 1.2 and 1.3 (IC50 values are 26, 150 and 338 nM respectively), compared to muscle subtypes NaV1.4 and 1.5 (IC50 = >10 μM). Inhibits the channel by binding at the neurotoxin receptor site 4 in the S3-S4 linker of domain II, trapping the voltage sensor in the inward, closed configuration.
Molecular Weight: 4106, 79
