Product Overview
JH-RE-06 | T15611 | TargetMol Chemicals
CAS: 1361227-90-8
Smiles: CC(C)CC(=O)c1c(Nc2ccc(Cl)cc2Cl)[nH]c2c(Cl)ccc([N+]([O-])=O)c2c1=O
Formula: C20H16Cl3N3O4
Pathway: Cell Cycle/Checkpoint|||DNA Damage/DNA Repair
Target: DNA/RNA Synthesis
Receptor: N/A
Bioactivity: JH-RE-06 disrupts mutagenic translesion synthesis (TLS) by preventing the recruitment of mutagenic POLζ. JH-RE-06 is an effective REV1-REV7 interface inhibitor (IC50=0.78 μM; Kd=0.42 μM), which targets REV1 that interacts with the REV7 subunit of POLζ. JH-RE-06 also improves chemotherapy.
Molecular Weight: 468, 72
