Product Overview
Pralsetinib | TQ0277 | TargetMol Chemicals
CAS: 2097132-94-8
Smiles: COC1(CCC(CC1)c1nc(C)cc(Nc2cc(C)[nH]n2)n1)C(=O)N[C@@H](C)c1ccc(nc1)-n1cc(F)cn1
Formula: C27H32FN9O2
Pathway: Apoptosis|||Tyrosine Kinase/Adaptors
Target: c-RET
Receptor: N/A
Bioactivity: Pralsetinib (BLU-667) is a highly potent, selective RET inhibitor (IC50s: 0.4, 0.3, 0.4, 0.4, and 0.4 nM for WT RET, RET mutants V804L, V804M, M918T and CCDC6-RET fusion).
Molecular Weight: 533, 612
