Product Overview
ZIP acetate(863987-12-6 free base) | TP1924L1 | TargetMol Chemicals
CAS: TP1924L1
Smiles:
Formula: C92H158N30O19
Pathway: Chromatin/Epigenetic|||Cytoskeletal Signaling
Target: PKC
Receptor: N/A
Bioactivity: ZIP acetate is a novel, cell-permeable inhibitor of protein kinase Mζ (PKMζ), a constitutively active, atypical PKC isozyme involved in LTP maintenance. Selectively blocks PKMζ-induced synaptic potentiation in hippocampal slices in vitro. Reverses late-phase LTP (IC50 = 1 - 2.5 μM) and produces persistent loss of 1-day-old spatial memory following central administration in vivo.
Molecular Weight: 1988, 43
